DELGADA

Deoxycholic Acid

Break down Fat cells

Active Ingredients

What is Deoxycholic acid?

As bile acid, Deoxycholic acid emulsifies fat. Synthetically derived deoxycholic acid disrupts the cell membrane

when injected, and causes adipic cytolysis to stimulate target decomposition of adipose cells.

Walker P, Lee D: A phase 1 pharmacokinetic study of ATX-101: serum lipids and adipokines following synthetic deoxycholic acid injections.

J Cosmet Dermatol. 2015 Mar;14(1):33-9. doi: 10.1111/jocd.12122. Epub 2015 Feb 14. [PubMed:25684122]

Why Deoxycholic Acid

The action of deoxycholic acid is reduced by albumin and tissue-related proteins, so its effect is limited to

subcutaneous fat tissues that lack protein. Protein-rich tissues such as muscles and skin contribute to its

safety without being affected by deoxycholic acid.

General References Wollina U, Goldman A: ATX-101 for reduction of submental fat. Expert Opin Pharmacother. 2015 Apr;16(5):755-62.

doi: 10.1517/14656566.2015.1019465. Epub 2015 Feb 27. [PubMed:25724831]